JRE 1854 · June 27, 2024
Rick Strassman
Who is Rick Strassman?
Rick Strassman is a Clinical Associate Professor of Psychiatry at the University of New Mexico School of Medicine. He is the author of numerous scientific papers and books, among them "DMT: The Spirit Molecule." His most recent, "The Psychedelic Handbook: A Practical Guide to Psilocybin, LSD, Ketamine, MDMA, and Ayahuasca," is available now. www.rickstrassman.com
Topics and Timestamps
- 01Rick Strassman discusses his research on DMT and its effects on human consciousness and spirituality
- 02The conversation covers his book 'The Psychedelic Handbook' which covers psilocybin, LSD, ketamine, MDMA, and ayahuasca
- 03Strassman explains the neurological and psychological mechanisms behind psychedelic experiences
- 04Discussion of clinical applications of psychedelics in treating depression, PTSD, and other mental health conditions
- 05The intersection of psychedelic experiences with spirituality, mysticism, and consciousness studies
- 06Practical guidance on set and setting for safe psychedelic experiences and integration afterward
- ▶Strassman explains the premise of his psychedelic handbook0:05:00
- ▶Discussion of how DMT works in the brain and consciousness0:15:30
- ▶The importance of set and setting in psychedelic experiences0:28:45
- ▶Clinical applications of psychedelics in treating mental health conditions0:42:00
- ▶Spiritual and mystical dimensions of psychedelic experiences0:58:15
The Show
Rick Strassman sits down with Joe to discuss his decades of research into psychedelics, particularly DMT, and his work developing practical frameworks for understanding and using these substances safely. Strassman brings serious scientific credibility to the conversation as a Clinical Associate Professor of Psychiatry at the University of New Mexico, and he's not shy about discussing what mainstream medicine is slowly catching up to: psychedelics have legitimate therapeutic potential.
The bulk of the discussion centers on Strassman's latest book, 'The Psychedelic Handbook,' which serves as a comprehensive guide to five major psychedelics: psilocybin, LSD, ketamine, MDMA, and ayahuasca. Rather than just talking about his earlier DMT work, Strassman frames psychedelics in a practical context for people actually considering using them. He breaks down what makes each substance unique, how they work in the brain, and what someone should expect. Joe and Rick dig into the subjective experience side while also grounding things in neuroscience, which is where these conversations get really interesting.
A key theme is set and setting, the classic psychedelic mantra that's actually backed by real research. Strassman emphasizes that your mental state going in and your physical environment matter enormously for what happens during a trip. He's clear that preparation and integration are as important as the experience itself. The conversation touches on how these substances are being studied for PTSD, depression, and end-of-life anxiety, clinical applications that weren't even being researched five or ten years ago.
Strassman doesn't shy away from the spiritual dimensions either. He acknowledges that many people report genuinely profound spiritual or mystical experiences on psychedelics, which is uncomfortable territory for some scientists but which he treats seriously. The discussion explores whether these experiences are purely neurological or point to something else, a question that hasn't been settled and probably won't be in our lifetime.
Throughout the conversation, Strassman maintains a tone of respect for both the power and the risk of these substances. He's not a cheerleader pushing everyone to try psychedelics, but rather someone who's spent his career studying them rigorously and believes they deserve that same serious attention from the medical and scientific community.
Best Quotes
“Psychedelics are tools, not toys. They deserve respect and preparation.”
— Rick Strassman
From the JRE 1854 conversation with Rick Strassman.
“Set and setting aren't just hippie talk, they're neurobiologically grounded in how these substances work.”
— Joe Rogan
From the JRE 1854 conversation with Rick Strassman.
“We're in a renaissance of psychedelic research after decades where this work was completely shut down.”
— Rick Strassman
From the JRE 1854 conversation with Rick Strassman.
“The spiritual experiences people report on psychedelics are real experiences, whether or not we can explain them fully.”
— Joe Rogan
From the JRE 1854 conversation with Rick Strassman.
“Integration is where the real work happens. The experience itself is just the beginning.”
— Rick Strassman
From the JRE 1854 conversation with Rick Strassman.
Mentioned in This Episode
Books, supplements, gear, and other cool things that came up in conversation — not the podcast ads.
DMT: The Spirit Molecule
AmazonStrassman's landmark book on his research into DMT and its effects on human consciousness and spirituality.
The Psychedelic Handbook: A Practical Guide to Psilocybin, LSD, Ketamine, MDMA, and Ayahuasca
AmazonStrassman's recent comprehensive guide covering five major psychedelics with practical information and safety guidelines.
As an Amazon Associate we earn from qualifying purchases.

